天侑六年，志宗崩逝，其次女公主楚九龄（彭小苒 饰）质疑其叔父弑君篡位。经历家破人亡等一系列突如其来的变故，九龄下定决心查清泽州隐秘，揭穿父皇被害真相，守护自己的至亲。九龄在成国公世子朱瓒（金瀚 饰）的帮助下坚持济世救人，不断地与奸佞的骚扰和攻击斗争，建立了医馆九龄堂，治痘疮，护百姓。与此同时，朱瓒与清贵公子宁云钊、前夫陆云旗、方家独子方承宇，身份各异、关系复杂的四人，陷入了以九龄为核心的感情漩涡。谁才是九龄的真命天子？命运齿轮，缓缓运转。
Sebastian pays tribute to a previous girlfriend, trying to produce the movie that she inspired him to write. He enlists Natalia, an empathic producer and his right hand, to help produce the film for which they struggle to find funding. Ultimately they decide to stage a play based on the script. Still hurting from his recent loss, Sebastian decides that he can’t start a new relationship. He goes in the opposite direction and takes irresponsible bachelorhood to the extreme. Success and fame open the door to encounters with all types of women who seem to fill the void that is becoming increasingly apparent in Sebastian’s life. Throughout this journey, Sebastian becomes even closer to Natalia. She is his friend and partner but there is an undeniable romantic tension. Blinded by his career and newfound relevance, Sebastian loses touch with his romantic nature. After bottling up their feelings, during a night of drinking Sebastian and Natalia cross a line. While Sebastian wonders if they made a mistake, Natalia feels ready for a relationship.
